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Mitochondrial Function in Astrocytes Is Essential for Normal Emergence from Anesthesia in Mice

Research Square

Research Square

  • First Author :
    Renjini Ramadasan-Nair
  • Co-authors :
    Jessica Hui;Leslie Itsara;Philip Morgan;Margaret Sedensky;
  • Journal Name :
    Anesthesiology
  • Read Full text :
  • DOI :
    10.1097/ALN.0000000000002528

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Abstract

In a tamoxifen-activated astrocyte-specific Ndufs4(KO) mouse, the induction EC50s for tail clamp in both isoflurane and halothane were similar between the control and astrocyte-specific Ndufs4(KO) mice at 3 weeks after 4-hydroxy tamoxifen injection. However, the emergent concentrations in both anesthetics for the astrocyte-specific Ndufs4(KO) mice were half that of the controls. Similarly, the induction EC50s for loss of righting reflex were similar between the control and astrocyte-specific Ndufs4(KO) mice; concentrations for regain of righting reflex in both anesthetics for the astrocyte-specific Ndufs4(KO) mice were much less than the control. Thus, mitochondrial complex I function within astrocytes is essential for normal emergence from anesthesia.

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